human MCFD2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MCFD2.
shADV-215169
Ad-h-MCFD2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MCFD2 (multiple coagulation factor deficiency 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
F5F8D; F5F8D2; LMAN1IP; SDNSF
Description (Vector)
MCFD2 encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
90411
Gene Name (Vector)
multiple coagulation factor deficiency 2
Gene Symbol
MCFD2
HGNC ID
HGNC:18451
ORF Size (aa)
285
RefSeq ID
NM_139279
RefSeq Synonyms
NM_139279, NM_001171511, NM_001171510, NM_001171509, NM_001171508, NM_001171507, NM_001171506, BC040357, BC037845,
Species
human
UniGene ID
Hs.293689
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.