human MAP3K7IP3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TAB3.
shADV-214941
Ad-h-MAP3K7IP3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MAP3K7IP3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
Description (eCommerce)
TAK1-binding protein 3 (TAB3) is a binding and regulatory subunit of the transforming growth factor-beta-activated kinase 1 (TAK1). TAB3 functions as an adaptor that mediates IL1 and TNF signaling pathways. Additionally it plays a role in the activation of the NF-kappaB pathway by functioning as receptors that bind polyubiquitin chains for the regulation of kinase activity.
Description (Vector)
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene ID
257397
Gene Name (eCommerce)
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Gene Name (Vector)
TGF-beta activated kinase 1/MAP3K7 binding protein 3
Gene Symbol
TAB3
HGNC ID
HGNC:30681
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2139
ORF Size (bp)
2139 bp
Protein Name (eCommerce)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
RefSeq ID
NM_152787
RefSeq Synonyms
NM_152787, BC032526,
Research Areas
B-cell Receptor Signaling,Cytokine Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TAK1-binding protein 3 (TAB3) is a binding and regulatory subunit of the transforming growth factor-beta-activated kinase 1 (TAK1). TAB3 functions as an adaptor that mediates IL1 and TNF signaling pathways. Additionally it plays a role in the activation of the NF-kappaB pathway by functioning as receptors that bind polyubiquitin chains for the regulation of kinase activity.
UniGene ID
Hs.188256
UniProt ID (eCommerce)
Q8N5C8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.