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human MAP3K7IP3 shRNA silencing AAV

Name 
AAV-h-MAP3K7IP3-shRNA
Cat No 
shAAV-214941
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TAB3.

shAAV-214941
AAV-h-MAP3K7IP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAP3K7IP3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NAP1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1 and MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
Description (eCommerce)
TAK1-binding protein 3 (TAB3) is a binding and regulatory subunit of the transforming growth factor-beta-activated kinase 1 (TAK1). TAB3 functions as an adaptor that mediates IL1 and TNF signaling pathways. Additionally it plays a role in the activation of the NF-kappaB pathway by functioning as receptors that bind polyubiquitin chains for the regulation of kinase activity.
Description (Vector)
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene ID
257397
Gene Name (eCommerce)
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Gene Name (Vector)
TGF-beta activated kinase 1/MAP3K7 binding protein 3
Gene Symbol
TAB3
HGNC ID
HGNC:30681
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2139
ORF Size (bp)
2139 bp
Protein Name (eCommerce)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
RefSeq ID
NM_152787
RefSeq Synonyms
NM_152787, BC032526,
Research Areas
B-cell Receptor Signaling,Cytokine Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
TAK1-binding protein 3 (TAB3) is a binding and regulatory subunit of the transforming growth factor-beta-activated kinase 1 (TAK1). TAB3 functions as an adaptor that mediates IL1 and TNF signaling pathways. Additionally it plays a role in the activation of the NF-kappaB pathway by functioning as receptors that bind polyubiquitin chains for the regulation of kinase activity.
UniGene ID
Hs.188256
UniProt ID (eCommerce)
Q8N5C8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.