human MAP3K5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MAP3K5.
shADV-214936
Ad-h-MAP3K5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ASK1; MAPKKK5; MEKK5
Description (Vector)
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Gene ID
4217
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 5
Gene Symbol
MAP3K5
HGNC ID
HGNC:6857
ORF Size (aa)
4125
ORF Size (bp)
4125 bp
RefSeq ID
NM_005923
RefSeq Synonyms
NM_005923, BC088829, BC054503,
Species
human
UniGene ID
Hs.186486
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.