human MAP2K1 shRNA silencing Adenovirus

CFC3; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEK1; MKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85% identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis.

MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

5604

mitogen-activated protein kinase kinase 1

mitogen-activated protein kinase kinase 1

MAP2K1

HGNC:6840

9606.0

1182

1182 bp

Dual specificity mitogen-activated protein kinase kinase 1

NM_002755

NM_002755, BC139729, BC137459,

Angiogenesis,Autophagy,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiomyopathy,Cardiovascular,Cell Cycle,Colorectal Cancer,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,GnRH Signaling,Golgi Apparatus,GPCR Signaling,Hedgehog Signaling,HGF Signaling,HIF-1 Signaling,Host-Virus Interactions,IFN Signaling,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Meiosis,MicroRNAs in Cancer,Mitochondrion,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,Phospho-specific,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,RANKL-RANK Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,TPO Signaling,TSH Signaling,TSLP Signaling,VEGF Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

human

MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85% identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis.

Hs.145442

Q02750