human LYN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LYN.
shADV-214712
Ad-h-LYN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LYN (LYN proto-oncogene, Src family tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
JTK8; lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Description (eCommerce)
LYN is a tyrosine protein kinase that acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. It is involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07948].
Description (Vector)
LYN encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
4067
Gene Name (eCommerce)
LYN proto-oncogene, Src family tyrosine kinase
Gene Name (Vector)
LYN proto-oncogene, Src family tyrosine kinase
Gene Symbol
LYN
HGNC ID
HGNC:6735
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1539
ORF Size (bp)
1539 bp
Protein Name (eCommerce)
Tyrosine-protein kinase Lyn
RefSeq ID
NM_002350
RefSeq Synonyms
NM_002350, NM_001111097, BC126458, BC126456, BC075002, BC075001,
Research Areas
Apoptosis,B-cell Receptor Signaling,Cancer,Cardiovascular,Cytokine Signaling,DNA Damage/Repair,EGFR Signaling,EPO Signaling,Fc Receptor Signaling,Golgi Apparatus,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,Neurodevelopment,NF-kB Signaling,PDGF Signaling,RANKL-RANK Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Tumor Suppressors/Oncoproteins,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
LYN is a tyrosine protein kinase that acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. It is involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P07948].
UniGene ID
Hs.699154
UniProt ID (eCommerce)
P07948
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.