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human LETM1 shRNA silencing Adenovirus

Name 
Ad-h-LETM1-shRNA
Cat No 
shADV-213839
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human LETM1.

shADV-213839
Ad-h-LETM1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
LETM1 and EF-hand domain-containing protein 1, mitochondrial; leucine zipper-EF-hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; mitochondrial proton/calcium exchanger protein; SLC55A1
Description (eCommerce)
LETM1 is localized to the inner mitochondrial membrane. LETM1 functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 3954)].
Description (Vector)
LETM1 encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.
Gene ID
3954
Gene Name (eCommerce)
leucine zipper and EF-hand containing transmembrane protein 1
Gene Name (Vector)
leucine zipper and EF-hand containing transmembrane protein 1
Gene Symbol
LETM1
HGNC ID
HGNC:6556
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2220
ORF Size (bp)
2220 bp
Protein Name (eCommerce)
LETM1 and EF-hand domain-containing protein 1, mitochondrial
RefSeq ID
NM_012318
RefSeq Synonyms
NM_012318, BC021208, BC014500,
Research Areas
Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
LETM1 is localized to the inner mitochondrial membrane. LETM1 functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4 [taken from NCBI Entrez Gene (Gene ID: 3954)].
UniGene ID
Hs.120165
UniProt ID (eCommerce)
O95202

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.