human KRAS shRNA silencing Adenovirus

cellular c-Ki-ras2 proto-oncogene;cellular transforming proto-oncogene;CFC2;c-Ki-ras;c-Ki-ras2;c-Kirsten-ras protein;C-K-RAS;GTPase KRas;KI-RAS;Kirsten rat sarcoma viral oncogene homolog;Kirsten rat sarcoma viral proto-oncogene;K-Ras;K-Ras 2;K-ras p21 protein;KRAS1;KRAS2;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;NS;NS3;oncogene KRAS2;PR310 c-K-ras oncogene;RALD;RASK2;transforming protein p21;v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. K-ras plays an important role in the regulation of cell proliferation and plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P01116].

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

3845

KRAS proto-oncogene, GTPase

KRAS proto-oncogene, GTPase

KRAS

HGNC:6407

9606.0

567

GTPase KRas

NM_004985

NM_033360, NM_004985, BC013572,

Angiogenesis,Apoptosis,Axon Guidance,B Cell Receptor Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Colorectal Cancer,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,GnRH Signaling,GPCR Signaling,HGF Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Leukemia,Lung Cancer,MAPK Signaling,Mitochondrion,mTOR Signaling,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,T Cell Receptor Signaling,VEGF Signaling,Viral Carcinogenesis

cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

human

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. K-ras plays an important role in the regulation of cell proliferation and plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P01116].

Hs.505033

P01116