human KLHL12 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KLHL12.
shADV-213228
Ad-h-KLHL12-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KLHL12 (kelch like family member 12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C3IP1; CUL3-interacting protein 1; DKIR; DKIR homolog; hDKIR; kelch-like protein 12; kelch-like protein C3IP1
Description (eCommerce)
Kelch-like protein 12 (KLHL12) serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. KLHL12 negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53G59].
Gene ID
59349
Gene Name (eCommerce)
kelch like family member 12
Gene Name (Vector)
kelch like family member 12
Gene Symbol
KLHL12
HGNC ID
HGNC:19360
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1707
ORF Size (bp)
1707 bp
Protein Name (eCommerce)
Kelch-like protein 12
RefSeq ID
NM_021633
RefSeq Synonyms
NM_021633, NM_001303109, NM_001303051, BC004175, BC003183,
Research Areas
Golgi Apparatus,Signal Transduction,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Kelch-like protein 12 (KLHL12) serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. KLHL12 negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53G59].
UniGene ID
Hs.706793
UniProt ID (eCommerce)
Q53G59
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.