human LEPREL1 Over-expression AAV

Name 
AAV-h-LEPREL1
Cat No 
AAV-213836
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human P3H2.

AAV-213836
AAV-h-LEPREL1

Ready-to-use AAV expressing Human P3H2 (prolyl 3-hydroxylase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LEPREL1; MCVD; MLAT4
Description (Vector)
LEPREL1 encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
55214
Gene Name (Vector)
prolyl 3-hydroxylase 2
Gene Symbol
P3H2
HGNC ID
HGNC:19317
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
RefSeq ID
NM_018192
RefSeq Synonyms
NM_018192, NM_001134418, BC005029,
Species
human
UniGene ID
Hs.374191

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.