human LEPR Over-expression AAV

Name 
AAV-h-LEPR
Cat No 
AAV-213834
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LEPR.

AAV-213834
AAV-h-LEPR

Ready-to-use AAV expressing Human LEPR (leptin receptor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD295; LEP-R; LEPRD; OB-R; OBR
Description (Vector)
LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
Gene ID
3953
Gene Name (Vector)
leptin receptor
Gene Symbol
LEPR
HGNC ID
HGNC:6554
ORF Size (aa)
3498
ORF Size (bp)
3498 bp
RefSeq ID
NM_002303
RefSeq Synonyms
NM_002303, NM_001198689, NM_001198688, NM_001198687, NM_001003680, NM_001003679, BC160009,
Species
human
UniGene ID
Hs.705413

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.