human KCNJ11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KCNJ11.
shADV-212712
Ad-h-KCNJ11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KCNJ11 (potassium voltage-gated channel subfamily J member 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BIR; HHF2; IKATP; KIR6.2; MODY13; PHHI; TNDM3
Description (Vector)
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Gene ID
3767
Gene Name (Vector)
potassium voltage-gated channel subfamily J member 11
Gene Symbol
KCNJ11
HGNC ID
HGNC:6257
ORF Size (aa)
1173
ORF Size (bp)
1173 bp
RefSeq ID
NM_000525
RefSeq Synonyms
NM_001166290, NM_000525, BC112358, BC064497,
Species
human
UniGene ID
Hs.248141
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.