human ITGAM shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ITGAM.
shADV-212492
Ad-h-ITGAM-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ITGAM (integrin subunit alpha M). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
antigen CD11b (p170); CD antigen CD11b; CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6
Description (eCommerce)
CD11b is the most commonly used name for Integrin alpha M (ITGAM). Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAM combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). ITGAM/ITGB2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. [taken from NCBI Entrez Gene (Gene ID: 3684)].
Description (Vector)
ITGAM encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
3684
Gene Name (eCommerce)
integrin subunit alpha M
Gene Name (Vector)
integrin subunit alpha M
Gene Symbol
ITGAM
HGNC ID
HGNC:6149
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3459
ORF Size (bp)
3459 bp
Protein Name (eCommerce)
Integrin alpha-M
RefSeq ID
NM_000632
RefSeq Synonyms
NM_001145808, NM_000632, BC099660, BC096348, BC096347, BC096346,
Research Areas
Cancer,Cardiovascular,Cytoskeleton,Immunology,Innate Immunity,Neurobiology,Neurodevelopment,Signal Transduction,Toll-like Receptor Signaling,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cardiovascular,cancer,cell_biology,developmental_biology,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
CD11b is the most commonly used name for Integrin alpha M (ITGAM). Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAM combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). ITGAM/ITGB2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. [taken from NCBI Entrez Gene (Gene ID: 3684)].
UniGene ID
Hs.172631
UniProt ID (eCommerce)
P11215
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.