human ITGAL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ITGAL.
shADV-212491
Ad-h-ITGAL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ITGAL (integrin subunit alpha L). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD11A; LFA-1; LFA1A
Description (Vector)
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
3683
Gene Name (Vector)
integrin subunit alpha L
Gene Symbol
ITGAL
HGNC ID
HGNC:6148
ORF Size (aa)
3261
ORF Size (bp)
3261 bp
RefSeq ID
NM_002209
RefSeq Synonyms
NM_002209, NM_001114380, BC008777,
Species
human
UniGene ID
Hs.174103
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.