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human IPO7 shRNA silencing Adenovirus

Name 
Ad-h-IPO7-shRNA
Cat No 
shADV-212349
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IPO7.

shADV-212349
Ad-h-IPO7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IPO7 (importin 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Imp7; importin-7; RAN-binding protein 7; RANBP7
Description (eCommerce)
Importin 7 autonomously mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. It binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 it mediates the nuclear import of H1 histone. In vitro, importin 7 mediates nuclear import of H2A, H2B, H3 and H4 histones. Also, in vitro, it mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase and HIF-1 alpha [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O95373].
Description (Vector)
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Gene ID
10527
Gene Name (eCommerce)
importin 7
Gene Name (Vector)
importin 7
Gene Symbol
IPO7
HGNC ID
HGNC:9852
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3117
ORF Size (bp)
3117 bp
Protein Name (eCommerce)
Importin-7
RefSeq ID
NM_006391
RefSeq Synonyms
NM_006391, BC114929,
Research Areas
Golgi Apparatus,Host-Virus Interactions,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,infectious_disease,signal_transduction
Species
human
Target Sentence
Importin 7 autonomously mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. It binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 it mediates the nuclear import of H1 histone. In vitro, importin 7 mediates nuclear import of H2A, H2B, H3 and H4 histones. Also, in vitro, it mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase and HIF-1 alpha [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O95373].
UniGene ID
Hs.718440
UniProt ID (eCommerce)
O95373

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.