human INSIG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human INSIG1.
shADV-212302
Ad-h-INSIG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human INSIG1 (insulin induced gene 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CL6
Description (Vector)
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
3638
Gene Name (Vector)
insulin induced gene 1
Gene Symbol
INSIG1
HGNC ID
HGNC:6083
ORF Size (aa)
834
RefSeq ID
NM_005542
RefSeq Synonyms
NM_198337, NM_198336, NM_005542, NM_001346594, NM_001346593, NM_001346592, NM_001346591, NM_001346590, BC001880,
Species
human
UniGene ID
Hs.520819
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.