human IL8RB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CXCR2.
shADV-212215
Ad-h-IL8RB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CXCR2 (C-X-C motif chemokine receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Description (Vector)
CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
3579
Gene Name (Vector)
C-X-C motif chemokine receptor 2
Gene Symbol
CXCR2
HGNC ID
HGNC:6027
ORF Size (aa)
1083
ORF Size (bp)
1083 bp
RefSeq ID
NM_001557
RefSeq Synonyms
NM_001557, NM_001168298, BC037961,
Species
human
UniGene ID
Hs.846
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.