human HYAL2 shRNA silencing Adenovirus

Name 
Ad-h-HYAL2-shRNA
Cat No 
shADV-211728
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HYAL2.

shADV-211728
Ad-h-HYAL2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HYAL2 (hyaluronoglucosaminidase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
LUCA2
Description (Vector)
HYAL2 encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. HYAL2 encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
Gene ID
8692
Gene Name (Vector)
hyaluronoglucosaminidase 2
Gene Symbol
HYAL2
HGNC ID
HGNC:5321
ORF Size (aa)
1422
ORF Size (bp)
1422 bp
RefSeq ID
NM_003773
RefSeq Synonyms
NM_033158, NM_003773, BC000692,
Species
human
UniGene ID
Hs.76873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.