human HNRNPK shRNA silencing Adenovirus

AUKS; CSBP; dC-stretch binding protein; heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRPK; transformation upregulated nuclear protein; Transformation up-regulated nuclear protein; TUNP

Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-K is a multifunctional protein implicated in chromatin remodeling, transcriptional control, translational control and RNA splicing. hnRNP-K has been found to function as a scaffolding protein that facilitates interaction between signaling kinases such as c-Src and factors that mediate mRNA-directed processes.

HNRNPK belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.

3190

heterogeneous nuclear ribonucleoprotein K

heterogeneous nuclear ribonucleoprotein K

HNRNPK

HGNC:5044

9606.0

1395

1395 bp

Heterogeneous nuclear ribonucleoprotein K

NM_002140

NM_031263, NM_031262, NM_002140, NM_001318188, NM_001318187, NM_001318186, BC014980, BC000355,

B-cell Receptor Signaling,Cancer,Gene Expression,Host-Virus Interactions,Immunology,MicroRNAs in Cancer,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Signal Transduction,Spliceosome,Transcription Factor/Regulator,Viral Carcinogenesis

cancer,cell_biology,genetics,transcription_translation,immunology,infectious_disease,signal_transduction

human

Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-K is a multifunctional protein implicated in chromatin remodeling, transcriptional control, translational control and RNA splicing. hnRNP-K has been found to function as a scaffolding protein that facilitates interaction between signaling kinases such as c-Src and factors that mediate mRNA-directed processes.

Hs.522257

P61978