human HMOX1 shRNA silencing Adenovirus

Name 
Ad-h-HMOX1-shRNA
Cat No 
shADV-211314
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HMOX1.

shADV-211314
Ad-h-HMOX1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HMOX1 (heme oxygenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bK286B10; heat shock protein, 32-kD; heme oxygenase (decycling) 1; heme oxygenase 1; HMOX1D; HO-1; HSP32
Description (eCommerce)
Heme oxygenase 1 (HO-1) cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618].
Description (Vector)
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
Gene ID
3162
Gene Name (eCommerce)
heme oxygenase 1
Gene Name (Vector)
heme oxygenase 1
Gene Symbol
HMOX1
HGNC ID
HGNC:5013
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
867
ORF Size (bp)
867 bp
Protein Name (eCommerce)
Heme oxygenase 1
RefSeq ID
NM_002133
RefSeq Synonyms
NM_002133, BC001491,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cardiovascular,Estrogen Signaling,HIF-1 Signaling,Hypoxia,Immunology,Interleukin Signaling,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Neurodegeneration,Neurodevelopment,NF-kB Signaling,Parkinson's Disease,Signal Transduction
Research Areas (Faceted)
cardiovascular,cancer,cell_biology,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Heme oxygenase 1 (HO-1) cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618].
UniGene ID
Hs.517581
UniProt ID (eCommerce)
P09601

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.