human LAS1L Over-expression AAV

Name 
AAV-h-LAS1L
Cat No 
AAV-213691
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LAS1L.

AAV-213691
AAV-h-LAS1L

Ready-to-use AAV expressing Human LAS1L (LAS1 like, ribosome biogenesis factor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dJ475B7.2; Las1-like; protein LAS1 homolog; ribosomal biogenesis protein LAS1L; WTS
Description (eCommerce)
LAS1L is involved in the biogenesis of the 60S ribosomal subunit. It is required for maturation of the 28S rRNA. LAS1L functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4W2].
Gene ID
81887
Gene Name (eCommerce)
LAS1 like, ribosome biogenesis factor
Gene Name (Vector)
LAS1 like, ribosome biogenesis factor
Gene Symbol
LAS1L
HGNC ID
HGNC:25726
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2154
ORF Size (bp)
2154 bp
Protein Name (eCommerce)
Ribosomal biogenesis protein LAS1L
RefSeq ID
NM_031206
RefSeq Synonyms
NM_031206, NM_001170650, NM_001170649, BC019302, BC018610, BC014545,
Research Areas
RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
LAS1L is involved in the biogenesis of the 60S ribosomal subunit. It is required for maturation of the 28S rRNA. LAS1L functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y4W2].
UniGene ID
Hs.522675
UniProt ID (eCommerce)
Q9Y4W2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.