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human HGF shRNA silencing Adenovirus

Name 
Ad-h-HGF-shRNA
Cat No 
shADV-210994
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HGF.

shADV-210994
Ad-h-HGF-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HGF (hepatocyte growth factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DFNB39; F-TCF; HGFB; HPTA; SF
Description (Vector)
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
Gene ID
3082
Gene Name (Vector)
hepatocyte growth factor
Gene Symbol
HGF
HGNC ID
HGNC:4893
ORF Size (aa)
2187
ORF Size (bp)
2187 bp
RefSeq ID
NM_000601
RefSeq Synonyms
NM_001010934, NM_001010933, NM_001010932, NM_001010931, NM_000601, BC130286, BC130284, BC063485,
Species
human
UniGene ID
Hs.396530

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.