human GPC3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GPC3.
shADV-210219
Ad-h-GPC3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GPC3 (glypican 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1
Description (Vector)
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Gene ID
2719
Gene Name (Vector)
glypican 3
Gene Symbol
GPC3
HGNC ID
HGNC:4451
ORF Size (aa)
1743
ORF Size (bp)
1743 bp
RefSeq ID
NM_004484
RefSeq Synonyms
NM_004484, NM_001164619, NM_001164618, NM_001164617, BC035972,
Species
human
UniGene ID
Hs.644108
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.