human GAMT shRNA silencing Adenovirus

Name 
Ad-h-GAMT-shRNA
Cat No 
shADV-209626
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GAMT.

shADV-209626
Ad-h-GAMT-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GAMT (guanidinoacetate N-methyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CCDS2; epididymis secretory protein Li 20; guanidinoacetate N-methyltransferase; HEL-S-20; PIG2; TP53I2
Description (eCommerce)
Guanidinoacetate N-methyltransferas (GAMT7) is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals [taken from NCBI Entrez Gene (Gene ID: 2593)].
Description (Vector)
GAMT is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13.
Gene ID
2593
Gene Name (eCommerce)
guanidinoacetate N-methyltransferase
Gene Name (Vector)
guanidinoacetate N-methyltransferase
Gene Symbol
GAMT
HGNC ID
HGNC:4136
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
711
ORF Size (bp)
711 bp
Protein Name (eCommerce)
Guanidinoacetate N-methyltransferase
RefSeq ID
NM_000156
RefSeq Synonyms
NM_138924, NM_000156, BC017936, BC016760,
Research Areas
Metabolism/Metabolic Process,Methyltransferase,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism
Species
human
Target Sentence
Guanidinoacetate N-methyltransferas (GAMT7) is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals [taken from NCBI Entrez Gene (Gene ID: 2593)].
UniGene ID
Hs.81131
UniProt ID (eCommerce)
Q14353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.