human G3BP2 shRNA silencing Adenovirus

Name
Ad-h-G3BP2-shRNA

Cat No
shADV-209477

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human G3BP2.

shADV-209477

Ad-h-G3BP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human G3BP2 (G3BP stress granule assembly factor 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

95

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

G3BP-2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; ras GTPase-activating protein-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2

Description (eCommerce)

Ras-GAP SH3 domain binding protein (G3BP2) contains an RNA recognition motif (RRM) and an N-terminal nuclear transport factor 2-like (NTF2-like) domain. The G3BP family of proteins have been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation.G3BP2 can interact with IkappaBalpha and IkappaBalpha/NFkappaB complexes. In this complex G3B2 is proposed to play a role in regulating the nucleocytoplasmic localization of NFkappaB as well as its activity.

Gene ID

9908

Gene Name (eCommerce)

G3BP stress granule assembly factor 2

Gene Name (Vector)

G3BP stress granule assembly factor 2

Gene Symbol

G3BP2

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1350

ORF Size (bp)

1350 bp

Protein Name (eCommerce)

Ras GTPase-activating protein-binding protein 2

RefSeq ID

NM_012297

RefSeq Synonyms

NM_203505, NM_203504, NM_012297, BC011731,

Research Areas

mRNA transport,RNA Binding,RNA Transport,Signal Transduction,TNF Signaling

Research Areas (Faceted)

signal_transduction,genetics,transcription_translation,cell_biology,signal_transduction

Species

human

Target Sentence

Ras-GAP SH3 domain binding protein (G3BP2) contains an RNA recognition motif (RRM) and an N-terminal nuclear transport factor 2-like (NTF2-like) domain. The G3BP family of proteins have been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation.G3BP2 can interact with IkappaBalpha and IkappaBalpha/NFkappaB complexes. In this complex G3B2 is proposed to play a role in regulating the nucleocytoplasmic localization of NFkappaB as well as its activity.

UniGene ID

Hs.303676

UniProt ID (eCommerce)

Q9UN86

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.