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human G3BP2 shRNA silencing AAV

Name 
AAV-h-G3BP2-shRNA
Cat No 
shAAV-209477
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human G3BP2.

shAAV-209477
AAV-h-G3BP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human G3BP2 (G3BP stress granule assembly factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
95
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
G3BP-2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; ras GTPase-activating protein-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2
Description (eCommerce)
Ras-GAP SH3 domain binding protein (G3BP2) contains an RNA recognition motif (RRM) and an N-terminal nuclear transport factor 2-like (NTF2-like) domain. The G3BP family of proteins have been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation.G3BP2 can interact with IkappaBalpha and IkappaBalpha/NFkappaB complexes. In this complex G3B2 is proposed to play a role in regulating the nucleocytoplasmic localization of NFkappaB as well as its activity.
Gene ID
9908
Gene Name (eCommerce)
G3BP stress granule assembly factor 2
Gene Name (Vector)
G3BP stress granule assembly factor 2
Gene Symbol
G3BP2
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1350
ORF Size (bp)
1350 bp
Protein Name (eCommerce)
Ras GTPase-activating protein-binding protein 2
RefSeq ID
NM_012297
RefSeq Synonyms
NM_203505, NM_203504, NM_012297, BC011731,
Research Areas
mRNA transport,RNA Binding,RNA Transport,Signal Transduction,TNF Signaling
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,cell_biology,signal_transduction
Species
human
Target Sentence
Ras-GAP SH3 domain binding protein (G3BP2) contains an RNA recognition motif (RRM) and an N-terminal nuclear transport factor 2-like (NTF2-like) domain. The G3BP family of proteins have been shown to function downstream of Ras and play a role in RNA metabolism, signal transduction, and proliferation.G3BP2 can interact with IkappaBalpha and IkappaBalpha/NFkappaB complexes. In this complex G3B2 is proposed to play a role in regulating the nucleocytoplasmic localization of NFkappaB as well as its activity.
UniGene ID
Hs.303676
UniProt ID (eCommerce)
Q9UN86

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.