human FLJ45422 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HLA-C.
shADV-209149
Ad-h-FLJ45422-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HLA-C (major histocompatibility complex, class I, C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D6S204; HLA-JY3; HLAC; HLC-C; MHC; PSORS1
Description (Vector)
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
Gene ID
3107
Gene Name (Vector)
major histocompatibility complex, class I, C
Gene Symbol
HLA-C
HGNC ID
HGNC:4933
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
RefSeq ID
NM_002117
RefSeq Synonyms
NM_002117, NM_001243042, BC033293, BC008457, BC002463,
Species
human
UniGene ID
Hs.656020
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.