human FHOD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FHOD1.
shADV-209019
Ad-h-FHOD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FHOD1 (formin homology 2 domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FH1/FH2 domain-containing protein 1; FHOS; formin homolog overexpressed in spleen 1; Formin homology 2 domain-containing protein 1
Description (eCommerce)
FHOD1 is required for the assembly of F-actin structures, such as stress fibers. It depends on the Rho-ROCK cascade for its activity. FHOD1 contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. It acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y613].
Description (Vector)
FHOD1 encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.
Gene ID
29109
Gene Name (eCommerce)
formin homology 2 domain containing 1
Gene Name (Vector)
formin homology 2 domain containing 1
Gene Symbol
FHOD1
HGNC ID
HGNC:17905
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3495
ORF Size (bp)
3495 bp
Protein Name (eCommerce)
FH1/FH2 domain-containing protein 1
RefSeq ID
NM_013241
RefSeq Synonyms
NM_013241, NM_001318202, BC033084,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
FHOD1 is required for the assembly of F-actin structures, such as stress fibers. It depends on the Rho-ROCK cascade for its activity. FHOD1 contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. It acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y613].
UniGene ID
Hs.95231
UniProt ID (eCommerce)
Q9Y613
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.