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human FHOD1 shRNA silencing AAV

Name 
AAV-h-FHOD1-shRNA
Cat No 
shAAV-209019
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FHOD1.

shAAV-209019
AAV-h-FHOD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FHOD1 (formin homology 2 domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FH1/FH2 domain-containing protein 1; FHOS; formin homolog overexpressed in spleen 1; Formin homology 2 domain-containing protein 1
Description (eCommerce)
FHOD1 is required for the assembly of F-actin structures, such as stress fibers. It depends on the Rho-ROCK cascade for its activity. FHOD1 contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. It acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y613].
Description (Vector)
FHOD1 encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.
Gene ID
29109
Gene Name (eCommerce)
formin homology 2 domain containing 1
Gene Name (Vector)
formin homology 2 domain containing 1
Gene Symbol
FHOD1
HGNC ID
HGNC:17905
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3495
ORF Size (bp)
3495 bp
Protein Name (eCommerce)
FH1/FH2 domain-containing protein 1
RefSeq ID
NM_013241
RefSeq Synonyms
NM_013241, NM_001318202, BC033084,
Research Areas
Cytoskeleton
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
FHOD1 is required for the assembly of F-actin structures, such as stress fibers. It depends on the Rho-ROCK cascade for its activity. FHOD1 contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. It acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y613].
UniGene ID
Hs.95231
UniProt ID (eCommerce)
Q9Y613

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.