human FBXW4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FBXW4.
shADV-208836
Ad-h-FBXW4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FBXW4 (F-box and WD repeat domain containing 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DAC; FBW4; FBWD4; SHFM3; SHSF3
Description (Vector)
FBXW4 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Gene ID
6468
Gene Name (Vector)
F-box and WD repeat domain containing 4
Gene Symbol
FBXW4
HGNC ID
HGNC:10847
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
RefSeq ID
NM_022039
RefSeq Synonyms
NM_022039, NM_001323541, BC063415, BC007380,
Species
human
UniGene ID
Hs.500822
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.