human ELL2 shRNA silencing Adenovirus

Name 
Ad-h-ELL2-shRNA
Cat No 
shADV-207844
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ELL2.

shADV-207844
Ad-h-ELL2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ELL2 (elongation factor for RNA polymerase II 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ELL-related RNA polymerase II, elongation factor; elongation factor RNA for polymerase II 2; elongation factor, RNA polymerase II, 2; metastatic renal cell carcinoma-associated transcript 1; MRCCAT1; RNA polymerase II elongation factor ELL2
Description (eCommerce)
ELL2 was identified as a homolog of the ELL (eleven-nineteen lysine-rich leukemia) gene, a frequent target for translocations in acute myeloid leukemia. ELL2 is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Gene ID
22936
Gene Name (eCommerce)
elongation factor for RNA polymerase II 2
Gene Name (Vector)
elongation factor for RNA polymerase II 2
Gene Symbol
ELL2
HGNC ID
HGNC:17064
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1923
ORF Size (bp)
1923 bp
Protein Name (eCommerce)
RNA polymerase II elongation factor ELL2
RefSeq ID
NM_012081
RefSeq Synonyms
NM_012081, BC028412,
Research Areas
RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
ELL2 was identified as a homolog of the ELL (eleven-nineteen lysine-rich leukemia) gene, a frequent target for translocations in acute myeloid leukemia. ELL2 is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
UniGene ID
Hs.708710
UniProt ID (eCommerce)
O00472

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.