human EIF2B5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EIF2B5.
shADV-207719
Ad-h-EIF2B5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CACH; CLE; EIF-2B; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2Bepsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; LVWM; translation initiation factor eIF-2B subunit epsilon
Description (eCommerce)
eIF2B5 is one of five subunits of the eukaryotic translation initiation factor 2B (eIF2B). eIF2B5 functions as a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in the EIF2B5 gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter (VWM) [taken from NCBI Entrez Gene (GeneID: 8893)].
Description (Vector)
EIF2B5 encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
Gene ID
8893
Gene Name (eCommerce)
eukaryotic translation initiation factor 2B subunit epsilon
Gene Name (Vector)
eukaryotic translation initiation factor 2B subunit epsilon
Gene Symbol
EIF2B5
HGNC ID
HGNC:3261
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2166
ORF Size (bp)
2166 bp
Protein Name (eCommerce)
Translation initiation factor eIF-2B subunit epsilon
RefSeq ID
NM_003907
RefSeq Synonyms
NM_003907, BC013590,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular,Gene Expression,Insulin Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,RNA Processing,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
signal_transduction,cardiovascular,genetics,transcription_translation,signal_transduction,metabolism,signal_transduction,neurobiology,genetics,transcription_translation,cell_biology,genetics
Species
human
Target Sentence
eIF2B5 is one of five subunits of the eukaryotic translation initiation factor 2B (eIF2B). eIF2B5 functions as a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in the EIF2B5 gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter (VWM) [taken from NCBI Entrez Gene (GeneID: 8893)].
UniGene ID
Hs.283551
UniProt ID (eCommerce)
Q13144
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.