human EIF2AK4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EIF2AK4.
shADV-207709
Ad-h-EIF2AK4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; PVOD2
Description (eCommerce)
GCN2 is a kinase that phosphorylates the alpha subunit of EIF2. GCN2 functions as a sensor of amino acid deficiency and modulates protein metabolism in response to cellular stress. GCN2 has also been reported to function in the regulation of lipid metabolism during amino acid deprivation.
Description (Vector)
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 (PubMed 10504407)).(supplied by OMIM, Mar 2008)
Gene ID
440275
Gene Name (eCommerce)
eukaryotic translation initiation factor 2 alpha kinase 4
Gene Name (Vector)
eukaryotic translation initiation factor 2 alpha kinase 4
Gene Symbol
EIF2AK4
HGNC ID
HGNC:19687
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4947
ORF Size (bp)
4947 bp
Protein Name (eCommerce)
eIF-2-alpha kinase GCN2
RefSeq ID
NM_001013703
RefSeq Synonyms
NM_001013703, BC146319, BC078179,
Research Areas
Host-Virus Interactions,Kinase/Phosphatase,Translational Control,tRNA Binding,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
GCN2 is a kinase that phosphorylates the alpha subunit of EIF2. GCN2 functions as a sensor of amino acid deficiency and modulates protein metabolism in response to cellular stress. GCN2 has also been reported to function in the regulation of lipid metabolism during amino acid deprivation.
UniGene ID
Hs.656673
UniProt ID (eCommerce)
Q9P2K8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.