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human E4F1 shRNA silencing Adenovirus

Name 
Ad-h-E4F1-shRNA
Cat No 
shADV-207504
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human E4F1.

shADV-207504
Ad-h-E4F1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human E4F1 (E4F transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E4F; E4F transcription factor 1; p120E4F; p50E4F; putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; transcription factor E4F; transcription factor E4F1
Description (eCommerce)
E4F1 is a Kruppel-like family member identified as a cellular protein activated by the viral E1A oncoprotein. E4F1 can function as an activator or repressor of transcription to control embryonic and somatic cell proliferation and survival. E4F1 has also been identified as an atypical ubiquitin E3 ligase for p53.
Description (Vector)
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
Gene ID
1877
Gene Name (eCommerce)
E4F transcription factor 1
Gene Name (Vector)
E4F transcription factor 1
Gene Symbol
E4F1
HGNC ID
HGNC:3121
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2355
ORF Size (bp)
2355 bp
Protein Name (eCommerce)
Transcription factor E4F1
RefSeq ID
NM_004424
RefSeq Synonyms
NM_004424, NM_001288778, NM_001288776, BC080524, BC014068,
Research Areas
Cell Cycle,Cell Division,DNA Replication,Host-Virus Interactions,Nuclear Receptor Coactivators,p53 Signaling,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,signal_transduction
Species
human
Target Sentence
E4F1 is a Kruppel-like family member identified as a cellular protein activated by the viral E1A oncoprotein. E4F1 can function as an activator or repressor of transcription to control embryonic and somatic cell proliferation and survival. E4F1 has also been identified as an atypical ubiquitin E3 ligase for p53.
UniGene ID
Hs.615283
UniProt ID (eCommerce)
Q66K89

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.