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human DYNLT1 shRNA silencing Adenovirus

Name 
Ad-h-DYNLT1-shRNA
Cat No 
shADV-207474
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DYNLT1.

shADV-207474
Ad-h-DYNLT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DYNLT1 (dynein light chain Tctex-type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CW-1; dynein light chain Tctex-type 1; Protein CW-1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1; TCTEL1; tctex-1
Description (eCommerce)
DYNLT1 is a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. DYNLT1 regulates the length of primary cilia which are sensory organelles found on the surface of cells. It interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. DYNLT1 protein also interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation [taken from NCBI Entrez Gene (Gene ID: 6993)].
Description (Vector)
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 (PubMed 15992542)).(supplied by OMIM, Mar 2008)
Gene ID
6993
Gene Name (eCommerce)
dynein light chain Tctex-type 1
Gene Name (Vector)
dynein light chain Tctex-type 1
Gene Symbol
DYNLT1
HGNC ID
HGNC:11697
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
342
Protein Name (eCommerce)
Dynein light chain Tctex-type 1
RefSeq ID
NM_006519
RefSeq Synonyms
NM_006519, NM_001291603, NM_001291602, BC105588, BC029412,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Golgi Apparatus,Host-Virus Interactions,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,neurobiology
Species
human
Target Sentence
DYNLT1 is a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. DYNLT1 regulates the length of primary cilia which are sensory organelles found on the surface of cells. It interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. DYNLT1 protein also interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation [taken from NCBI Entrez Gene (Gene ID: 6993)].
UniGene ID
Hs.445999
UniProt ID (eCommerce)
P63172

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.