human DVL2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DVL2.
shADV-207452
Ad-h-DVL2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DVL2 (dishevelled segment polarity protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; segment polarity protein dishevelled homolog DVL-2
Description (eCommerce)
Dishevelled 2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. Dishevelled 2 may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans [taken from NCBI Entrez Gene (Gene ID: 1856)].
Description (Vector)
DVL2 encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL2 encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Gene ID
1856
Gene Name (eCommerce)
dishevelled segment polarity protein 2
Gene Name (Vector)
dishevelled segment polarity protein 2
Gene Symbol
DVL2
HGNC ID
HGNC:3086
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
Protein Name (eCommerce)
Segment polarity protein dishevelled homolog DVL-2
RefSeq ID
NM_004422
RefSeq Synonyms
NM_004422, BC014844,
Research Areas
Cancer,Cardiac Development,Cardiology,Cardiovascular,DNA Damage/Repair,Hippo Signaling,Host-Virus Interactions,JNK Signaling,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Dishevelled 2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. Dishevelled 2 may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans [taken from NCBI Entrez Gene (Gene ID: 1856)].
UniGene ID
Hs.118640
UniProt ID (eCommerce)
O14641
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.