human DSP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DSP.
shADV-207358
Ad-h-DSP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DSP (desmoplakin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; desmoplakin; DP
Description (eCommerce)
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].
Description (Vector)
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Gene ID
1832
Gene Name (eCommerce)
desmoplakin
Gene Name (Vector)
desmoplakin
Gene Symbol
DSP
HGNC ID
HGNC:3052
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6819
ORF Size (bp)
6819 bp
Protein Name (eCommerce)
Desmoplakin
RefSeq ID
NM_004415
RefSeq Synonyms
NM_004415, NM_001319034, NM_001008844, BC140802,
Research Areas
Apoptosis,Cardiac Development,Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,EGFR Signaling,Mitochondrion,Signal Transduction,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in DSP, the gene encoding desmoplakin, are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus [taken from NCBI Entrez Gene (Gene ID: 1832)].
UniGene ID
Hs.519873
UniProt ID (eCommerce)
P15924
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.