human DDX42 shRNA silencing Adenovirus

Name 
Ad-h-DDX42-shRNA
Cat No 
shADV-206762
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DDX42.

shADV-206762
Ad-h-DDX42-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DDX42 (DEAD-box helicase 42). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATP-dependent RNA helicase DDX42; DDX42P; DEAD (Asp-Glu-Ala-Asp) box helicase 42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; DEAD box protein 42; RHELP; RNA helicase-like protein; RNA helicase-related protein; RNAHP; SF3b DEAD box protein; SF3b125; SF3B8; splicing factor 3b, subunit 8; splicing factor 3B-associated 125 kDa protein
Description (eCommerce)
DDX42 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. DDX42 has been shown to interact with ASPP2 and modulate its function as a stimulator of apoptosis.
Description (Vector)
DDX42 encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.
Gene ID
11325
Gene Name (eCommerce)
DEAD-box helicase 42
Gene Name (Vector)
DEAD-box helicase 42
Gene Symbol
DDX42
HGNC ID
HGNC:18676
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2817
ORF Size (bp)
2817 bp
Protein Name (eCommerce)
ATP-dependent RNA helicase DDX42
RefSeq ID
NM_007372
RefSeq Synonyms
NM_203499, NM_007372, BC093081, BC015505,
Research Areas
Apoptosis,Gene Expression,Helicase Activity,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DDX42 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. DDX42 has been shown to interact with ASPP2 and modulate its function as a stimulator of apoptosis.
UniGene ID
Hs.702010
UniProt ID (eCommerce)
Q86XP3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.