human KDM5A Adenovirus
This is an Adenovirus expressing Human DDX42.
ADV-212849
Ad-h-KDM5A
Ready-to-use Adenovirus expressing Human KDM5A (lysine demethylase 5A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
histone demethylase JARID1A; Jumonji, AT rich interactive domain 1A (RBP2-like); jumonji/ARID domain-containing protein 1A; lysine (K)-specific demethylase 5A; lysine-specific demethylase 5A; RBBP2; RBBP-2; RBP2; retinoblastoma binding protein 2; Retinoblastoma-binding protein 2
Description (eCommerce)
JARID1A/RBP2 is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JARID1A/RBP2 functions to specifically demethylate lys-4 of histone 3 and interacts with the tumor suppressor protein pRb.
Description (Vector)
KDM5A is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein.
Gene ID
5927
Gene Name (eCommerce)
lysine demethylase 5A
Gene Name (Vector)
lysine demethylase 5A
Gene Symbol
KDM5A
HGNC ID
HGNC:9886
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4923
ORF Size (bp)
4923 bp
Protein Name (eCommerce)
Lysine-specific demethylase 5A
RefSeq ID
NM_001042603
RefSeq Synonyms
NM_001042603, BC172533, BC156461,
Research Areas
Cancer,Chromatin Remodeling,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
JARID1A/RBP2 is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JARID1A/RBP2 functions to specifically demethylate lys-4 of histone 3 and interacts with the tumor suppressor protein pRb.
UniGene ID
Hs.76272
UniProt ID (eCommerce)
P29375
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.