human DBNL shRNA silencing Adenovirus

Name 
Ad-h-DBNL-shRNA
Cat No 
shADV-206627
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DBNL.

shADV-206627
Ad-h-DBNL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DBNL (drebrin like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ABP1; actin-binding protein 1; cervical mucin-associated protein; cervical SH3P7; drebrin-F; drebrin-like protein; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; SH3P7; src homology 3 domain-containing protein HIP-55
Description (eCommerce)
HIP55 (HPK1-interacting protein of 55 kDa) is an actin-binding adapter protein that may act as a common effector of antigen receptor-signaling pathways in leukocytes. The association of HIP55 with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. HIP55 acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJU6].
Gene ID
28988
Gene Name (eCommerce)
drebrin like
Gene Name (Vector)
drebrin like
Gene Symbol
DBNL
HGNC ID
HGNC:2696
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Drebrin-like protein
RefSeq ID
NM_014063
RefSeq Synonyms
NM_014063, NM_001284315, NM_001284313, NM_001122956, NM_001014436, BC031687, BC011677,
Research Areas
Apoptosis,Cytoskeleton,Golgi Apparatus,Immunology,Neurobiology,Signal Transduction,Synapse,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
HIP55 (HPK1-interacting protein of 55 kDa) is an actin-binding adapter protein that may act as a common effector of antigen receptor-signaling pathways in leukocytes. The association of HIP55 with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. HIP55 acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UJU6].
UniGene ID
Hs.436500
UniProt ID (eCommerce)
Q9UJU6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.