human CRYBB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CRYBB2.
shADV-206058
Ad-h-CRYBB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CRYBB2 (crystallin beta B2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CCA2; CRYB2; CRYB2A; CTRCT3; D22S665
Description (Vector)
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.
Gene ID
1415
Gene Name (Vector)
crystallin beta B2
Gene Symbol
CRYBB2
HGNC ID
HGNC:2398
ORF Size (aa)
618
ORF Size (bp)
618 bp
RefSeq ID
NM_000496
RefSeq Synonyms
NM_000496, BC069535,
Species
human
UniGene ID
Hs.373074
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.