human CREB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CREB1.
shADV-205972
Ad-h-CREB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CREB1 (cAMP responsive element binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; transactivator protein
Description (eCommerce)
CREB (cyclic AMP response element-binding protein) is a ubiquitously expressed transcription factor that binds cAMP response elements to regulate gene transcription for various cellular responses such as glucose homeostasis, growth-factor dependent survival, and proliferation. CREB is also implicated to play a role in memory and mood.
Description (Vector)
CREB1 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
1385
Gene Name (eCommerce)
cAMP responsive element binding protein 1
Gene Name (Vector)
cAMP responsive element binding protein 1
Gene Symbol
CREB1
HGNC ID
HGNC:2345
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
984
ORF Size (bp)
984 bp
Protein Name (eCommerce)
Cyclic AMP-responsive element-binding protein 1
RefSeq ID
NM_004379
RefSeq Synonyms
NM_134442, NM_004379, NM_001320793, BC095407, BC010636,
Research Areas
Alzheimer's Disease,Antigen Processing and Presentation,Apoptosis,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,Host-Virus Interactions,Huntington's Disease,Hypoxia,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Leptin Signaling,LKB1 Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,NGF Signaling,Notch Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TSH Signaling,VEGF Signaling,Viral Carcinogenesis,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
CREB (cyclic AMP response element-binding protein) is a ubiquitously expressed transcription factor that binds cAMP response elements to regulate gene transcription for various cellular responses such as glucose homeostasis, growth-factor dependent survival, and proliferation. CREB is also implicated to play a role in memory and mood.
UniGene ID
Hs.516646
UniProt ID (eCommerce)
P16220
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.