human COX10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human COX10.
shADV-205812
Ad-h-COX10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human COX10 (COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
Gene ID
1352
Gene Name (Vector)
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
Gene Symbol
COX10
HGNC ID
HGNC:2260
ORF Size (aa)
1332
ORF Size (bp)
1332 bp
RefSeq ID
NM_001303
RefSeq Synonyms
NM_001303, BC006394, BC000060,
Species
human
UniGene ID
Hs.462278
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.