human COPS8 shRNA silencing Adenovirus

Name
Ad-h-COPS8-shRNA

Cat No
shADV-205777

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human COPS8.

shADV-205777

Ad-h-COPS8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human COPS8 (COP9 signalosome subunit 8). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

COP9; CSN8; SGN8

Description (Vector)

COPS8 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene ID

10920

Gene Name (Vector)

COP9 signalosome subunit 8

Gene Symbol

COPS8

HGNC ID

HGNC:24335

ORF Size (aa)

630

ORF Size (bp)

630 bp

RefSeq ID

NM_006710

RefSeq Synonyms

NM_198189, NM_006710, BC080617, BC036499, BC003090,

Species

human

UniGene ID

Hs.531713

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.