Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human CENPT shRNA silencing Adenovirus

Name 
Ad-h-CENPT-shRNA
Cat No 
shADV-204975
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CENPT.

shADV-204975
Ad-h-CENPT-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CENPT (centromere protein T). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C16orf56; CENP-T; centromere protein T; interphase centromere complex protein 22
Description (eCommerce)
Centromere protein T (CENP-T) is a component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENP-T is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96BT3].
Description (Vector)
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 (PubMed 16622419)).(supplied by OMIM, Mar 2008)
Gene ID
80152
Gene Name (eCommerce)
centromere protein T
Gene Name (Vector)
centromere protein T
Gene Symbol
CENPT
HGNC ID
HGNC:25787
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1686
ORF Size (bp)
1686 bp
Protein Name (eCommerce)
Centromere protein T
RefSeq ID
NM_025082
RefSeq Synonyms
NM_025082, BC015202,
Research Areas
Cell Cycle,Cell Division
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Centromere protein T (CENP-T) is a component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENP-T is one of the basic inner kinetochore proteins with most further proteins binding downstream, suggesting a fundamental role of CENP-T in kinetochore function [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96BT3].
UniGene ID
Hs.288382
UniProt ID (eCommerce)
Q96BT3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.