human CD96 shRNA silencing Adenovirus

Name 
Ad-h-CD96-shRNA
Cat No 
shADV-204701
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CD96.

shADV-204701
Ad-h-CD96-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CD96 (CD96 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD96; cell surface antigen CD96; T cell activation, increased late expression; t cell-activated increased late expression protein; TACTILE; T-cell surface protein tactile
Description (eCommerce)
CD96 is an immunoglobulin superfamily member involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. CD96 promotes NK cell-target cell adhesion by interacting with PVR present on target cells. CD96 may function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P40200].
Description (Vector)
CD96 belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
Gene ID
10225
Gene Name (eCommerce)
CD96 molecule
Gene Name (Vector)
CD96 molecule
Gene Symbol
CD96
HGNC ID
HGNC:16892
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
Protein Name (eCommerce)
T-cell surface protein tactile
RefSeq ID
NM_005816
RefSeq Synonyms
NM_198196, NM_005816, NM_001318889, BC020749,
Research Areas
Immunology,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
CD96 is an immunoglobulin superfamily member involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. CD96 promotes NK cell-target cell adhesion by interacting with PVR present on target cells. CD96 may function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P40200].
UniGene ID
Hs.142023
UniProt ID (eCommerce)
P40200

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.