human CD74 shRNA silencing Adenovirus

Name 
Ad-h-CD74-shRNA
Cat No 
shADV-204680
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CD74.

shADV-204680
Ad-h-CD74-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CD74 (CD74 molecule). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD74; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DHLAG; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLADG; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; II; MHC HLA-DR gamma chain; p33
Description (eCommerce)
CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 also serves as cell surface receptor for the cytokine MIF. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P04233].
Description (Vector)
CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
972
Gene Name (eCommerce)
CD74 molecule
Gene Name (Vector)
CD74 molecule
Gene Symbol
CD74
HGNC ID
HGNC:1697
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
699
ORF Size (bp)
699 bp
Protein Name (eCommerce)
HLA class II histocompatibility antigen gamma chain
RefSeq ID
NM_004355
RefSeq Synonyms
NM_004355, NM_001025159, NM_001025158, BC024272, BC018726,
Research Areas
Antigen Processing and Presentation,Apoptosis,DNA Damage/Repair,Golgi Apparatus,Host-Virus Interactions,Immunology,Lysosome,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,genetics,transcription_translation,cell_biology,infectious_disease,immunology,cell_biology
Species
human
Target Sentence
CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 also serves as cell surface receptor for the cytokine MIF. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P04233].
UniGene ID
Hs.436568
UniProt ID (eCommerce)
P04233

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.