human CD247 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human CD247.
shADV-204612
Ad-h-CD247-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human CD247 (CD247 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD247; CD247 antigen, zeta subunit; CD3H; CD3Q; CD3; ZCD3Z antigen, zeta polypeptide (TiT3 complex); CD3-ZETA; CD3zeta chain; IMD25; T3; ZT-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 zeta chain; T-cell surface glycoprotein CD3 zeta chain; TCR zeta chain; TCRZ
Description (eCommerce)
T-cell surface glycoprotein CD3 zeta chain is encoded by the gene CD247, also known as CD3Z or CD3 zeta. CD247/CD3 zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response [taken from NCBI Entrez Gene (Gene ID: 919)].
Description (Vector)
CD247 is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene ID
919
Gene Name (eCommerce)
CD247 molecule
Gene Name (Vector)
CD247 molecule
Gene Symbol
CD247
HGNC ID
HGNC:1677
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
495
ORF Size (bp)
495 bp
Protein Name (eCommerce)
T-cell surface glycoprotein CD3 zeta chain
RefSeq ID
NM_000734
RefSeq Synonyms
NM_198053, NM_000734, BC025703,
Research Areas
Apoptosis,Breast Cancer,Cancer,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology,infectious_disease,immunology,signal_transduction
Species
human
Target Sentence
T-cell surface glycoprotein CD3 zeta chain is encoded by the gene CD247, also known as CD3Z or CD3 zeta. CD247/CD3 zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response [taken from NCBI Entrez Gene (Gene ID: 919)].
UniGene ID
Hs.156445
UniProt ID (eCommerce)
P20963
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.