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human CBX5 shRNA silencing Adenovirus

Name 
Ad-h-CBX5-shRNA
Cat No 
shADV-204200
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CBX5.

shADV-204200
Ad-h-CBX5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CBX5 (chromobox 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
antigen p25; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha; HP1 alpha homolog; HP1A; HP1-ALPHA; HP1Hs alpha
Description (eCommerce)
CBX5 (chromobox protein homolog 5), also known as HP1 (heterochromatin protein 1 homolog alpha), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.
Description (Vector)
CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
23468
Gene Name (eCommerce)
chromobox 5
Gene Name (Vector)
chromobox 5
Gene Symbol
CBX5
HGNC ID
HGNC:1555
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
576
ORF Size (bp)
576 bp
Protein Name (eCommerce)
Chromobox protein homolog 5
RefSeq ID
NM_012117
RefSeq Synonyms
NM_012117, NM_001127322, NM_001127321, BC006821,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Complexome,Host-Virus Interactions,Polycomb Proteins,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,signal_transduction
Species
human
Target Sentence
CBX5 (chromobox protein homolog 5), also known as HP1 (heterochromatin protein 1 homolog alpha), is one of 3 isoforms of HP1 that binds heterochromatin and functions as a structural adaptor to stabilize and organize macromolecular complexes with nucleosomes for higher chromatin structure. All of the HP1 isoforms possess a chromodomain and chromoshadow domain and associate with methylated histones that mediate transcriptional repression.
UniGene ID
Hs.349283
UniProt ID (eCommerce)
P45973

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.