mouse CBX5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Cbx5.
shAAV-254637
AAV-m-CBX5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Cbx5 (chromobox 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610029O15Rik; C75991; HP1; Hp1a; Hp1alpha
Description (Vector)
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Gene ID
12419
Gene Name (Vector)
chromobox 5
Gene Symbol
Cbx5
ORF Size (aa)
576
ORF Size (bp)
576 bp
RefSeq ID
NM_007626
RefSeq Synonyms
NM_007626, NM_001110216, NM_001076789, BC004707,
Species
mouse
UniGene ID
Mm.262059
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.